[Use of beta 1-adrenostimulants in circulatory failure in patients with chronic inflammatory lung diseases]. / Primenenie beta 1-adrenostimuliatorov pri nedostatochnosti krovoobrashcheniia u bol'nykh s khronicheskimi vospalitel'nymi zabolevaniiami legkikh.

In 34 patients with chronic cor pulmonale, the drugs from a group of beta-adrenostimulants, nonachlazinum and oxyphedrinum, were tested for effects on their hemodynamics, pulmonary ventilation function, blood gas composition and acid-base balance. In patients with circulatory failure due to lung diseases, nonachlazinum and oxyphedrinum were found to exert a pronounced positive intropic action, to contribute to an increase in cardiac output. The agents may be included into the multimodality therapy of patients with decompensated chronic cor pulmonale.

[The effect of ibuprofen on the hemodynamics of the lesser circulation in patients with pulmonary hypertension]. / Vliianie ibuprofena na sostoianie gemodinamiki malogo kruga u bol'nykh s legochnoi gipertenziei.

The effect of ibuprofen on pulmonary circulation hemodynamics, pulmonary ventilation and blood gaseous metabolism was studied under conditions of cardiac venous catheterization in 8 patients with pulmonary hypertension caused by chronic inflammatory diseases of the lungs. After oral use of ibuprofen in a dose of 0.4 g, there was (in 7 out of the 8 patients) an increase in the right ventricle systolic pressure at an average by 5.9 +/- 2.39 mm Hg (p less than 0.05). The time course of the echocardiographic indices in the majority of the patients was evident of an increase in the right ventricle postload. No definite tendencies in changing of pulmonary ventilation and blood gaseous metabolism were observed. Inhibition of synthesis of prostacyclin and type E prostaglandin having a vasodilating action is the most likely mechanism of the ibuprofen vasoconstrictive effect.